HIP2

UBE2K
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1YLA, 2O25, 3E46, 3F92, 3K9O, 3K9P, 5DFL
معین‌کننده‌ها
نام‌های دیگر	UBE2K, E2-25K, HIP2, HYPG, LIG, UBC1, ubiquitin conjugating enzyme E2 K
شناسه‌های بیرونی	OMIM: 602846 MGI: 1858216 HomoloGene: 3903 GeneCards: UBE2K
موقعیت ژن (موش)
کروموزوم	کروموزوم ۵ (موش)
پایان	65,756,331 bp
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0050372 ubiquitin-protein transferase activity; • transferase activity; • nucleotide binding; • ubiquitin-ubiquitin ligase activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • ATP binding; • ubiquitin protein ligase binding; • ubiquitin conjugating enzyme activity;
ترکیبات سلولی	• سیتوپلاسم; • filopodium tip; • هسته یاخته; • سیتوزول;
فرایند زیستی	• protein K48-linked ubiquitination; • positive regulation of type I interferon-mediated signaling pathway; • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; • free ubiquitin chain polymerization; • positive regulation of peptidyl-threonine phosphorylation; • ubiquitin-dependent protein catabolic process; • cellular response to interferon-beta; • proteasome-mediated ubiquitin-dependent protein catabolic process; • regulation of proteasomal ubiquitin-dependent protein catabolic process; • protein ubiquitination;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	3093
	53323
	ENSG00000078140
	ENSMUSG00000029203
	P61086
	P61087
	NM_001111112، NM_001111113، NM_001312646، NM_001312647، NM_001312648، NM_032733، XM_047450156، XM_047450157، XM_047450158 NM_005339، NM_001111112، NM_001111113، NM_001312646، NM_001312647، NM_001312648، NM_032733، XM_047450156، XM_047450157، XM_047450158
	NM_001310618، NM_001310619، NR_144566 NM_016786، NM_001310618، NM_001310619، NR_144566
	NP_001104583، NP_001299575، NP_001299576، NP_001299577، NP_005330 NP_001104582، NP_001104583، NP_001299575، NP_001299576، NP_001299577، NP_005330
	NP_001297548، NP_058066 NP_001297547، NP_001297548، NP_058066
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

آنزیم E2 K جفت‌شونده با یوبیکوتین (انگلیسی: Ubiquitin-conjugating enzyme E2 K) یک پروتئین است که در انسان توسط ژن «UBE2K» کُدگذاری می‌شود.^[۴]^[۵]^[۶]

اهمیت بالینی

این آنزیم در تجزیهٔ هانتینگتین و سرکوب آپوپتوز نقش دارد.^[۶]

منابع

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029203 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kalchman MA, Graham RK, Xia G, Koide HB, Hodgson JG, Graham KC, Goldberg YP, Gietz RD, Pickart CM, Hayden MR (Sep 1996). "Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme". J Biol Chem. 271 (32): 19385–94. doi:10.1074/jbc.271.32.19385. PMID 8702625.
↑ Christensen DE, Brzovic PS, Klevit RE (Oct 2007). "E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages". Nat Struct Mol Biol. 14 (10): 941–8. doi:10.1038/nsmb1295. PMID 17873885.
1 2 "Entrez Gene: HIP2 huntingtin interacting protein 2".

مشارکت‌کنندگان ویکی‌پدیا. «HIP2». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۵ ژوئن ۲۰۱۹.

برای مطالعهٔ بیشتر

Petersén A, Mani K, Brundin P (1999). "Recent advances on the pathogenesis of Huntington's disease". Exp. Neurol. 157 (1): 1–18. doi:10.1006/exnr.1998.7006. PMID 10222105.
Coux O, Goldberg AL (1998). "Enzymes catalyzing ubiquitination and proteolytic processing of the p105 precursor of nuclear factor kappaB1". J. Biol. Chem. 273 (15): 8820–8. doi:10.1074/jbc.273.15.8820. PMID 9535861.
Whitby FG, Xia G, Pickart CM, Hill CP (1999). "Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes". J. Biol. Chem. 273 (52): 34983–91. doi:10.1074/jbc.273.52.34983. PMID 9857030.
Kikuchi J, Furukawa Y, Kubo N, Tokura A, Hayashi N, Nakamura M, Matsuda M, Sakurabayashi I (2000). "Induction of ubiquitin-conjugating enzyme by aggregated low density lipoprotein in human macrophages and its implications for atherosclerosis". Arterioscler. Thromb. Vasc. Biol. 20 (1): 128–34. doi:10.1161/01.ATV.20.1.128. PMID 10634809.
Furukawa Y, Kubo N, Kikuchi J, Tokura A, Fujita N, Sakurabayashi I (2000). "Regulation of macrophage-specific gene expression by degenerated lipoproteins". Electrophoresis. 21 (2): 338–46. doi:10.1002/(SICI)1522-2683(20000101)21:2<338::AID-ELPS338>3.0.CO;2-9. PMID 10675012.
Lee SJ, Choi JY, Sung YM, Park H, Rhim H, Kang S (2001). "E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme". FEBS Lett. 503 (1): 61–4. doi:10.1016/S0014-5793(01)02689-8. PMID 11513855.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Goehler H, Lalowski M, Stelzl U, Waelter S, Stroedicke M, Worm U, Droege A, Lindenberg KS, Knoblich M, Haenig C, Herbst M, Suopanki J, Scherzinger E, Abraham C, Bauer B, Hasenbank R, Fritzsche A, Ludewig AH, Büssow K, Buessow K, Coleman SH, Gutekunst CA, Landwehrmeyer BG, Lehrach H, Wanker EE (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Flierman D, Coleman CS, Pickart CM, Rapoport TA, Chau V (2006). "E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system". Proc. Natl. Acad. Sci. U.S.A. 103 (31): 11589–94. doi:10.1073/pnas.0605215103. PMC 1520313. PMID 16868077.
de Pril R, Fischer DF, Roos RA, van Leeuwen FW (2007). "Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases". Mol. Cell. Neurosci. 34 (1): 10–9. doi:10.1016/j.mcn.2006.09.006. PMID 17092742.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029203 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8702625-4] Kalchman MA, Graham RK, Xia G, Koide HB, Hodgson JG, Graham KC, Goldberg YP, Gietz RD, Pickart CM, Hayden MR (Sep 1996). "Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme". J Biol Chem. 271 (32): 19385–94. doi:10.1074/jbc.271.32.19385. PMID 8702625.

[pmid17873885-5] Christensen DE, Brzovic PS, Klevit RE (Oct 2007). "E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages". Nat Struct Mol Biol. 14 (10): 941–8. doi:10.1038/nsmb1295. PMID 17873885.

[entrez-6] 1 2 "Entrez Gene: HIP2 huntingtin interacting protein 2".

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