GRIN1

GRIN1
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	2HQW, 2NR1, 3BYA, 5H8N, 5H8H, 5H8Q, 5H8F, 5I2N, 5I2K, 5KCJ, 5KDT
معین‌کننده‌ها
نام‌های دیگر	GRIN1, GluN1, MRD8, NMDA1, NMDAR1, NR1, NMD-R1, glutamate ionotropic receptor NMDA type subunit 1, NDHMSR, NDHMSD, DEE101
شناسه‌های بیرونی	OMIM: 138249 MGI: 95819 HomoloGene: 7187 GeneCards: GRIN1
موقعیت ژن (موش)
کروموزوم	کروموزوم ۲ (موش)
پایان	25,209,199 bp
الگوی گسترش RNA
	; ; ; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• calcium ion binding; • signaling receptor binding; • glycine binding; • calmodulin binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • cation channel activity; • extracellularly glutamate-gated ion channel activity; • glutamate binding; • calcium channel activity; • NMDA glutamate receptor activity; • ion channel activity; • ionotropic glutamate receptor activity; • neurotransmitter binding; • transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; • amyloid-beta binding; • glutamate-gated calcium ion channel activity; • signaling receptor activity; • GO:0032403 protein-containing complex binding;
ترکیبات سلولی	• سیتوپلاسم; • postsynaptic membrane; • membrane; • سیناپس; • NMDA selective glutamate receptor complex; • neuron projection; • synaptic vesicle; • dendritic spine; • cell surface; • شبکه آندوپلاسمی; • integral component of membrane; • پوسته یاخته; • GO:0097483، GO:0097481 postsynaptic density; • integral component of plasma membrane; • سیناپس تحریکی; • پیوند میان‌یاخته‌ای; • دندریت; • synaptic cleft; • پایانه آکسون; • postsynaptic density membrane; • synaptic membrane; • glutamatergic synapse; • integral component of postsynaptic density membrane;
فرایند زیستی	• GO:1904089 negative regulation of neuron apoptotic process; • pons maturation; • synaptic transmission, glutamatergic; • regulation of respiratory gaseous exchange; • response to amphetamine; • regulation of membrane potential; • regulation of synapse assembly; • یادگیری; • positive regulation of excitatory postsynaptic potential; • response to ethanol; • calcium ion transport; • suckling behavior; • prepulse inhibition; • male mating behavior; • regulation of long-term neuronal synaptic plasticity; • adult locomotory behavior; • regulation of neuron apoptotic process; • ion transport; • حافظه; • regulation of axonogenesis; • neuromuscular process; • ionotropic glutamate receptor signaling pathway; • excitatory postsynaptic potential; • learning or memory; • رفتار اجتماعی; • regulation of neuronal synaptic plasticity; • associative learning; • واکنش یکه خوردن; • calcium ion homeostasis; • cation transport; • cellular calcium ion homeostasis; • cation transmembrane transport; • respiratory gaseous exchange by respiratory system; • regulation of synaptic plasticity; • response to morphine; • propylene metabolic process; • بیزاری شرطی از مزه; • cerebral cortex development; • GO:0015915 transport; • درد نوسیسپتیو; • olfactory learning; • regulation of cell communication; • یادگیری بصری; • ephrin receptor signaling pathway; • MAPK cascade; • regulation of dendrite morphogenesis; • ion transmembrane transport; • حافظه بلندمدت; • positive regulation of apoptotic process; • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II; • GO:0032320، GO:0032321، GO:0032855، GO:0043089، GO:0032854 positive regulation of GTPase activity; • calcium ion transmembrane transport; • regulation of ion transmembrane transport; • brain development; • positive regulation of calcium ion transport into cytosol; • calcium-mediated signaling; • protein heterotetramerization; • GO:0060401 calcium ion transmembrane import into cytosol; • excitatory chemical synaptic transmission; • positive regulation of reactive oxygen species biosynthetic process; • protein localization to postsynaptic membrane; • cellular response to amyloid-beta; • response to glycine; • positive regulation of cysteine-type endopeptidase activity; • regulation of NMDA receptor activity;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	2902
	14810
	ENSG00000176884
	ENSMUSG00000026959
	Q05586
	P35438
	NM_000832، NM_001185090، NM_001185091، NM_007327، NM_021569، XM_005266071، XM_005266072، XM_005266073 XM_011518583، NM_000832، NM_001185090، NM_001185091، NM_007327، NM_021569، XM_005266071، XM_005266072، XM_005266073
	NM_001177657، NM_008169، NM_001372558، NM_001372559، NM_001372560، NM_001372561، NM_001372562 NM_001177656، NM_001177657، NM_008169، NM_001372558، NM_001372559، NM_001372560، NM_001372561، NM_001372562
	NP_001172019، NP_001172020، NP_015566، NP_067544، XP_005266128، XP_005266129، XP_005266130، XP_011516885 NP_000823، NP_001172019، NP_001172020، NP_015566، NP_067544، XP_005266128، XP_005266129، XP_005266130، XP_011516885
	NP_001171128، NP_032195، NP_001359487، NP_001359488، NP_001359489، NP_001359490، NP_001359491 NP_001171127، NP_001171128، NP_032195، NP_001359487، NP_001359488، NP_001359489، NP_001359490، NP_001359491
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

گیرندهٔ گلوتامات [ان‌ام‌دی‌اِی]، زیرواحد زتا-۱ (انگلیسی: Glutamate [NMDA] receptor subunit zeta-1) یک پروتئین است که در انسان توسط ژن «GRIN1» کُدگذاری می‌شود.^[۴]^[۵]

پروتئینی که توسط این ژن کُد می‌شود، زیرواحد مهمی از «گیرنده‌های ان‌ام‌دی‌ای» است. این زیرواحدها با کمک هم، یک کانال یونی دریچه-لیگاندی ایجاد می‌کنند و نقش کلیدی در انعطاف‌پذیری در سیناپس‌هایی دارند که در یادگیری و حافظه مؤثرند. این ژن اگزون دارد. به نظر می‌رسد عوامل خاص یاخته‌ای در شکل‌گیری ایزوفرم‌های مختلف این پروتئین نقش داشته و در بروز گوناگونی عملکردی زیرواحدهای آن دخیل هستند.^[۵]

منابع

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026959 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H, Burnashev N, Sakmann B, Seeburg PH (Jun 1992). "Heteromeric NMDA receptors: molecular and functional distinction of subtypes". Science. 256 (5060): 1217–21. doi:10.1126/science.256.5060.1217. PMID 1350383.
1 2 "Entrez Gene: GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1".

مشارکت‌کنندگان ویکی‌پدیا. «GRIN1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۲ سپتامبر ۲۰۲۰.

برای مطالعهٔ بیشتر

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[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026959 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1350383-4] Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H, Burnashev N, Sakmann B, Seeburg PH (Jun 1992). "Heteromeric NMDA receptors: molecular and functional distinction of subtypes". Science. 256 (5060): 1217–21. doi:10.1126/science.256.5060.1217. PMID 1350383.

[entrez-5] 1 2 "Entrez Gene: GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1".

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