GPR143
| پروتئین ۱ آلبینیسم چشمی | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| شناسهها | |||||||||
| نماد | Ocular_alb | ||||||||
| پیفم | PF02101 | ||||||||
| پیفم clan | CL0192 | ||||||||
| اینترپرو | IPR001414 | ||||||||
| |||||||||
گیرندهٔ شمارهٔ ۱۴۳ جفتشونده با پروتئین جی (انگلیسی: G protein-coupled receptor 143) یک پروتئین است که در انسان توسط ژن «GPR143» کُدگذاری میشود. [۴][۵][۶]
این پروتئین که با نام «پروتئین ۱ آلبینیسم چشمی» یا OA1 هم شناخته میشود، یک پروتئین یکپارچه و محافظتشدهٔ پوستهٔ سلول است که هفت دومین تراغشایی دارد و در چشم و ملانوسیتهای روپوست بیان میگردد.[۶]
ژن GPR143 توسط فاکتور رونویسی مرتبط با میکروفتالمی تنظیم میشود.[۷][۸]
لوودوپا، یک لیگاند درونزاد برای OA1 است.[۹]
این پروتئین با GNAI1 تعامل پروتئین-پروتئین دارد.[۵]
منابع
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025333 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Bassi MT, Schiaffino MV, Renieri A, De Nigris F, Galli L, Bruttini M, Gebbia M, Bergen AA, Lewis RA, Ballabio A (Sep 1995). "Cloning of the gene for ocular albinism type 1 from the distal short arm of the X chromosome". Nat Genet. 10 (1): 13–9. doi:10.1038/ng0595-13. PMID 7647783.
- 1 2 Schiaffino MV, d'Addio M, Alloni A, Baschirotto C, Valetti C, Cortese K, Puri C, Bassi MT, Colla C, De Luca M, Tacchetti C, Ballabio A (Sep 1999). "Ocular albinism: evidence for a defect in an intracellular signal transduction system". Nat Genet. 23 (1): 108–12. doi:10.1038/12715. PMID 10471510.
- 1 2 "Entrez Gene: GPR143 G protein-coupled receptor 143".
- ↑ Vetrini F, Auricchio A, Du J, et al. (2004). "The microphthalmia transcription factor (Mitf) controls expression of the ocular albinism type 1 gene: link between melanin synthesis and melanosome biogenesis". Mol. Cell. Biol. 24 (15): 6550–9. doi:10.1128/MCB.24.15.6550-6559.2004. PMC 444869. PMID 15254223.
- ↑ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
- ↑ Lopez VM, Decatur CL, Stamer WD, Lynch RM, McKay BS (September 2008). Barsh GS (ed.). "L-DOPA is an endogenous ligand for OA1". PLoS Biol. 6 (9): e236. doi:10.1371/journal.pbio.0060236. PMC 2553842. PMID 18828673.
- مشارکتکنندگان ویکیپدیا. «GPR143». در دانشنامهٔ ویکیپدیای انگلیسی، بازبینیشده در ۳۰ دسامبر ۲۰۱۸.
برای مطالعهٔ بیشتر
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