تناسین سی

TNC
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1TEN, 2RB8, 2RBL
معین‌کننده‌ها
نام‌های دیگر	TNC, 150-225, DFNA56, GMEM, GP, HXB, JI, TN, TN-C, Tenascin C
شناسه‌های بیرونی	OMIM: 187380 MGI: 101922 HomoloGene: 55636 GeneCards: TNC
موقعیت ژن (موش)
کروموزوم	کروموزوم ۴ (موش)
پایان	63,965,252 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• syndecan binding; • extracellular matrix structural constituent; • GO:0001948، GO:0016582 پیوند پروتئینی;
ترکیبات سلولی	• interstitial matrix; • membrane; • focal adhesion; • GO:0005578 بافت‌مانه برون‌یاخته‌ای; • غشای پایه; • extracellular space; • endoplasmic reticulum lumen; • extracellular region; • collagen-containing extracellular matrix; • perisynaptic extracellular matrix;
فرایند زیستی	• cellular response to retinoic acid; • negative regulation of cell adhesion; • bud outgrowth involved in lung branching; • mesenchymal-epithelial cell signaling involved in prostate gland development; • response to fibroblast growth factor; • response to mechanical stimulus; • extracellular matrix organization; • بهبود زخم; • cellular response to vitamin D; • odontogenesis of dentin-containing tooth; • GO:1901313 positive regulation of gene expression; • چسبندگی سلولی; • prostate gland epithelium morphogenesis; • cellular response to prostaglandin D stimulus; • regulation of cell population proliferation; • neuromuscular junction development; • response to wounding; • peripheral nervous system axon regeneration; • osteoblast differentiation; • positive regulation of cell population proliferation; • response to ethanol; • neuron projection development; • پیرایش پسارونویسی;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	3371
	21923
	ENSG00000041982
	ENSMUSG00000028364
	P24821
	Q80YX1
	XM_005251972، XM_005251973، XM_005251974، XM_005251975، XM_006717096، XM_006717097، XM_006717098، XM_006717101، XM_011518625، XM_011518626، XM_011518628، XM_011518629، XM_017014678، XM_017014679، XM_017014680، XM_017014681، XM_024447530 NM_002160، XM_005251972، XM_005251973، XM_005251974، XM_005251975، XM_006717096، XM_006717097، XM_006717098، XM_006717101، XM_011518625، XM_011518626، XM_011518628، XM_011518629، XM_017014678، XM_017014679، XM_017014680، XM_017014681، XM_024447530
	XM_006537776، NM_001369211، NM_001369212، NM_001369213، NM_001369214 NM_011607، XM_006537776، NM_001369211، NM_001369212، NM_001369213، NM_001369214
	XP_005252029، XP_005252030، XP_005252031، XP_005252032، XP_006717159، XP_006717160، XP_006717161، XP_006717164، XP_011516927، XP_011516928، XP_011516930، XP_011516931، XP_016870167، XP_016870168، XP_016870169، XP_016870170، XP_024303298 NP_002151، XP_005252029، XP_005252030، XP_005252031، XP_005252032، XP_006717159، XP_006717160، XP_006717161، XP_006717164، XP_011516927، XP_011516928، XP_011516930، XP_011516931، XP_016870167، XP_016870168، XP_016870169، XP_016870170، XP_024303298
	XP_006537839، NP_001356140، NP_001356141، NP_001356142، NP_001356143 NP_035737، XP_006537839، NP_001356140، NP_001356141، NP_001356142، NP_001356143
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

تناسین سی (انگلیسی: Tenascin C) یک گلیکوپروتئین است که در انسان توسط ژن «TNC» کُد می‌شود.^[۴]^[۵] این پروتئین در ماتریکس برون‌یاخته‌ای بسیاری از بافت‌ها در حین «تکامل»، «بیماری» یا «آسیب» و همچنین در برخی مناطق دارای قابلیت عصب‌زایی در دستگاه عصبی مرکزی، بیان می‌شود.^[۶]^[۷] این پروتئین نخستین عضو از خانوادهٔ تناسین‌هاست. در رویان، این پروتئین در سلول‌های مهاجرت‌کننده همچون ستیغ عصبی تولید می‌شود. همچنین در بافت‌هایی نظیر تاندون‌ها، استخوان و غضروف به فراوانی یافت می‌شود.

پژوهش‌هایی در جریان است تا از تناسین سی به‌عنوان یک نشانگر زیستی در برخی بیماری‌ها نظیر میوکاردیت^[۸] و بعضی از سرطان‌ها استفاده شود.

تناسین سی در تعدادی از سرطان‌ها استئوسارکوما،^[۹] کوندروسارکوما،^[۱۰] سرطان مثانه^[۱۱] و گلیوبلاستوما^[۱۲] دخیل است.

منابع

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028364 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nies DE, Hemesath TJ, Kim JH, Gulcher JR, Stefansson K (March 1991). "The complete cDNA sequence of human hexabrachion (Tenascin). A multidomain protein containing unique epidermal growth factor repeats". J Biol Chem. 266 (5): 2818–23. PMID 1704365.
↑ Siri A, Carnemolla B, Saginati M, Leprini A, Casari G, Baralle F, Zardi L (May 1991). "Human tenascin: primary structure, pre-mRNA splicing patterns and localization of the epitopes recognized by two monoclonal antibodies". Nucleic Acids Res. 19 (3): 525–31. doi:10.1093/nar/19.3.525. PMC 333643. PMID 1707164.
↑ Midwood, Kim S.; Hussenet, Thomas; Langlois, Benoit; Orend, Gertraud (5 August 2011). "Advances in tenascin-C biology". Cellular and Molecular Life Sciences. 68 (19): 3175–3199. doi:10.1007/s00018-011-0783-6.
↑ Wiese S, Karus M, Faissner A (2012). "Astrocytes as a source for extracellular matrix molecules and cytokines". Front Pharmacol. 3: 120. doi:10.3389/fphar.2012.00120. PMC 3382726. PMID 22740833.
↑ Imanaka-Yoshida K, Hiroe M, Yasutomi Y, Toyozaki T, Tsuchiya T, Noda N, Maki T, Nishikawa T, Sakakura T, Yoshida T (2002). "Tenascin-C is a useful marker for disease activity in myocarditis". J. Pathol. 197 (3): 388–94. doi:10.1002/path.1131. PMID 12115886.
↑ Tanaka M, Yamazaki T, Araki N, Yoshikawa H, Yoshida T, Sakakura T, Uchida A (2000). "Clinical significance of tenascin-C expression in osteosarcoma: tenascin-C promotes distant metastases of osteosarcoma". Int. J. Mol. Med. 5 (5): 505–10. doi:10.3892/ijmm.5.5.505. PMID 10762653.
↑ Ghert MA, Jung ST, Qi W, Harrelson JM, Erickson HP, Block JA, Scully SP (2001). "The clinical significance of tenascin-C splice variant expression in chondrosarcoma". Oncology. 61 (4): 306–14. doi:10.1159/000055338. PMID 11721178.
↑ Brunner A, Mayerl C, Tzankov A, Verdorfer I, Tschörner I, Rogatsch H, Mikuz G (2004). "Prognostic significance of tenascin-C expression in superficial and invasive bladder cancer". J. Clin. Pathol. 57 (9): 927–31. doi:10.1136/jcp.2004.016576. PMC 1770417. PMID 15333651.
↑ Herold-Mende C, Mueller MM, Bonsanto MM, Schmitt HP, Kunze S, Steiner HH (March 2002). "Clinical impact and functional aspects of tenascin-C expression during glioma progression". Int. J. Cancer. 98 (3): 362–9. doi:10.1002/ijc.10233. PMID 11920587.

مشارکت‌کنندگان ویکی‌پدیا. «Tenascin C». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۴ دسامبر ۲۰۱۷.

بیشتر بخوانید

Imanaka-Yoshida K, Hiroe M, Yoshida T (2004). "Interaction between cell and extracellular matrix in heart disease: multiple roles of tenascin-C in tissue remodeling". Histol. Histopathol. 19 (2): 517–25. PMID 15024713.
Leahy DJ, Hendrickson WA, Aukhil I, Erickson HP (1992). "Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein". Science. 258 (5084): 987–91. doi:10.1126/science.1279805. PMID 1279805.
White DM, Mikol DD, Espinosa R, et al. (1992). "Structure and chromosomal localization of the human gene for a brain form of prostaglandin D2 synthase". J. Biol. Chem. 267 (32): 23202–8. PMID 1385416.
Gulcher JR, Nies DE, Marton LS, Stefansson K (1989). "An alternatively spliced region of the human hexabrachion contains a repeat of potential N-glycosylation sites". Proc. Natl. Acad. Sci. U.S.A. 86 (5): 1588–92. doi:10.1073/pnas.86.5.1588. PMC 286743. PMID 2466295.
Yokosaki Y, Palmer EL, Prieto AL, et al. (1994). "The integrin alpha 9 beta 1 mediates cell attachment to a non-RGD site in the third fibronectin type III repeat of tenascin". J. Biol. Chem. 269 (43): 26691–6. PMID 7523411.
Glumoff V, Savontaus M, Vehanen J, Vuorio E (1994). "Analysis of aggrecan and tenascin gene expression in mouse skeletal tissues by northern and in situ hybridization using species specific cDNA probes". Biochim. Biophys. Acta. 1219 (3): 613–22. doi:10.1016/0167-4781(94)90220-8. PMID 7524681.
Gherzi R, Carnemolla B, Siri A, et al. (1995). "Human tenascin gene. Structure of the 5'-region, identification, and characterization of the transcription regulatory sequences". J. Biol. Chem. 270 (7): 3429–34. doi:10.1074/jbc.270.7.3429. PMID 7531707.
Weinacker A, Ferrando R, Elliott M, et al. (1995). "Distribution of integrins alpha v beta 6 and alpha 9 beta 1 and their known ligands, fibronectin and tenascin, in human airways". Am. J. Respir. Cell Mol. Biol. 12 (5): 547–56. doi:10.1165/ajrcmb.12.5.7537970. PMID 7537970.
Schnapp LM, Hatch N, Ramos DM, et al. (1995). "The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin". J. Biol. Chem. 270 (39): 23196–202. doi:10.1074/jbc.270.39.23196. PMID 7559467.
Sriramarao P, Mendler M, Bourdon MA (1993). "Endothelial cell attachment and spreading on human tenascin is mediated by alpha 2 beta 1 and alpha v beta 3 integrins". J. Cell Sci. 105 (4): 1001–12. PMID 7693733.
Prieto AL, Edelman GM, Crossin KL (1993). "Multiple integrins mediate cell attachment to cytotactin/tenascin". Proc. Natl. Acad. Sci. U.S.A. 90 (21): 10154–8. doi:10.1073/pnas.90.21.10154. PMC 47732. PMID 7694284.
Zagzag D, Friedlander DR, Dosik J, et al. (1996). "Tenascin-C expression by angiogenic vessels in human astrocytomas and by human brain endothelial cells in vitro". Cancer Res. 56 (1): 182–9. PMID 8548761.
Burg MA, Tillet E, Timpl R, Stallcup WB (1996). "Binding of the NG2 proteoglycan to type VI collagen and other extracellular matrix molecules". J. Biol. Chem. 271 (42): 26110–6. doi:10.1074/jbc.271.42.26110. PMID 8824254.
Rauch U, Clement A, Retzler C, et al. (1997). "Mapping of a defined neurocan binding site to distinct domains of tenascin-C". J. Biol. Chem. 272 (43): 26905–12. doi:10.1074/jbc.272.43.26905. PMID 9341124.

[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028364 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1704365-4] Nies DE, Hemesath TJ, Kim JH, Gulcher JR, Stefansson K (March 1991). "The complete cDNA sequence of human hexabrachion (Tenascin). A multidomain protein containing unique epidermal growth factor repeats". J Biol Chem. 266 (5): 2818–23. PMID 1704365.

[pmid1707164-5] Siri A, Carnemolla B, Saginati M, Leprini A, Casari G, Baralle F, Zardi L (May 1991). "Human tenascin: primary structure, pre-mRNA splicing patterns and localization of the epitopes recognized by two monoclonal antibodies". Nucleic Acids Res. 19 (3): 525–31. doi:10.1093/nar/19.3.525. PMC 333643. PMID 1707164.

[6] Midwood, Kim S.; Hussenet, Thomas; Langlois, Benoit; Orend, Gertraud (5 August 2011). "Advances in tenascin-C biology". Cellular and Molecular Life Sciences. 68 (19): 3175–3199. doi:10.1007/s00018-011-0783-6.

[Wiese-7] Wiese S, Karus M, Faissner A (2012). "Astrocytes as a source for extracellular matrix molecules and cytokines". Front Pharmacol. 3: 120. doi:10.3389/fphar.2012.00120. PMC 3382726. PMID 22740833.

[pmid12115886-8] Imanaka-Yoshida K, Hiroe M, Yasutomi Y, Toyozaki T, Tsuchiya T, Noda N, Maki T, Nishikawa T, Sakakura T, Yoshida T (2002). "Tenascin-C is a useful marker for disease activity in myocarditis". J. Pathol. 197 (3): 388–94. doi:10.1002/path.1131. PMID 12115886.

[pmid10762653-9] Tanaka M, Yamazaki T, Araki N, Yoshikawa H, Yoshida T, Sakakura T, Uchida A (2000). "Clinical significance of tenascin-C expression in osteosarcoma: tenascin-C promotes distant metastases of osteosarcoma". Int. J. Mol. Med. 5 (5): 505–10. doi:10.3892/ijmm.5.5.505. PMID 10762653.

[pmid11721178-10] Ghert MA, Jung ST, Qi W, Harrelson JM, Erickson HP, Block JA, Scully SP (2001). "The clinical significance of tenascin-C splice variant expression in chondrosarcoma". Oncology. 61 (4): 306–14. doi:10.1159/000055338. PMID 11721178.

[pmid15333651-11] Brunner A, Mayerl C, Tzankov A, Verdorfer I, Tschörner I, Rogatsch H, Mikuz G (2004). "Prognostic significance of tenascin-C expression in superficial and invasive bladder cancer". J. Clin. Pathol. 57 (9): 927–31. doi:10.1136/jcp.2004.016576. PMC 1770417. PMID 15333651.

[Herold-12] Herold-Mende C, Mueller MM, Bonsanto MM, Schmitt HP, Kunze S, Steiner HH (March 2002). "Clinical impact and functional aspects of tenascin-C expression during glioma progression". Int. J. Cancer. 98 (3): 362–9. doi:10.1002/ijc.10233. PMID 11920587.

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